(DOWNLOADABLE)This technical report provides guidance on the development of cleaning processes for dental instruments, and their validation, as one of the steps in a multi-step instrument reprocessing procedure. It applies to cleaning prior to initial use as well as reuse. Validated cleaning processes are important in achieving consistently clean and biocompatible instruments, thereby mitigating the risk of cross contamination. This technical report does not address the disinfection, inspection and sterilization steps of reprocessing dental instruments.